Reference # | Publication | PDB | Chain | Mutation(s) | Change in Stability | Change in Activity | Prediction | Percentage Change | Protherm Status | Correct | Total | Total Enzyme | Non Enzyme Total |

1 | Disulfide bond-deficient azurin mutant | 1AZU | _ | 3ALA/26ALA | Decreased Stability | NA | -4.46 | -22.53 | None | Y | 237 | Correct | Correct |

1 | Disulfide bond-deficient azurin mutant | 1AZU | _ | 3ALA/26ILE | Decreased Stability | NA | -3.19 | -16.11 | None | Y | 17 | 169 | |

1 | Disulfide bond-deficient azurin mutant | 1AZU | _ | 3ALA/25ARG/26ALA/27ARG | Decreased Stability | NA | -5.25 | -24.17 | None | Y | Total Correct | Incorrect | Incorrect |

2 | In-vitro selection of highly stabilized mutants | 1CSQ | _ | 66LEU/67PRO | Increased Stability | NA | 0.34 | 4.63 | None | Y | 186 | 10 | 41 |

2 | In-vitro selection of highly stabilized mutants | 1CSQ | _ | 2ILE/3SER/46GLN/64LEU/66LEU/67PRO | Increased Stability | NA | 0.6 | 2.1 | None | Y | Percentage | Percentage | |

2 | In-vitro selection of highly stabilized mutants | 1CSQ | _ | 46LEU/66LEU/67HIS | Increased Stability | NA | 0.58 | 4.82 | None | Y | Total Incorrect | 62.96% | 80.48% |

2 | In-vitro selection of highly stabilized mutants | 1CSQ | _ | 2TYR/3ARG/46LEU | Increased Stability | NA | 0.66 | 3.7 | None | Y | 51 | ||

2 | In-vitro selection of highly stabilized mutants | 1CSQ | _ | 2TYR/3ILE/46GLN/64LEU/66LEU/67PRO | Increased Stability | NA | 0.99 | 4.03 | None | Y | |||

3 | Contribution of tryptophan to the properties of ribotoxin -sarcin | 1DE3 | A | 4PHE | Decreased Stability | NA | 2.89 | 16.25 | None | N | Total Percentage | ||

3 | Contribution of tryptophan to the properties of ribotoxin -sarcin | 1DE3 | A | 51PHE | Decreased Stability | NA | 0.92 | 7.76 | None | N | 77.97% | ||

3 | Contribution of tryptophan to the properties of ribotoxin -sarcin | 1DE3 | A | 4PHE/51PHE | Decreased Stability | NA | 3.21 | 12.37 | None | N | |||

4 | Reduction of hydrophobicity in bacteriorhodopsin | 1DZE | A | 113GLN | Decreased Stability | NA | -0.26 | -2.58 | None | Y | |||

4 | Reduction of hydrophobicity in bacteriorhodopsin | 1DZE | A | 113GLN/116GLN | Decreased Stability | NA | -0.7 | -4.64 | None | Y | |||

4 | Reduction of hydrophobicity in bacteriorhodopsin | 1DZE | A | 113GLN/116GLN/120GLN | Decreased Stability | NA | -1.02 | -4.61 | None | Y | |||

4 | Reduction of hydrophobicity in bacteriorhodopsin | 1DZE | A | 113GLN/116GLN/120GLN/124GLN | Decreased Stability | NA | -1.71 | -5.92 | None | Y | |||

4 | Reduction of hydrophobicity in bacteriorhodopsin | 1DZE | A | 113GLN/116GLN/117ASP/120GLN/124GLN | Decreased Stability | NA | -6.73 | -19.42 | None | Y | |||

5 | Mutagenesis of protein phosphatase 1 | 1FJM | A | 124ASP | Increased Stability | Loss of E Act | -0.22 | -1.47 | None | N | Both | N | |

5 | Mutagenesis of protein phosphatase 2 | 1FJM | A | 248ASN | Increased Stability | Loss of E Act | -6.4 | -28.49 | None | N | Both | N | |

5 | Mutagenesis of protein phosphatase 3 | 1FJM | A | 96ALA | Increased Stability | Loss of E Act | -0.3 | -3.23 | None | N | Both | N | |

5 | Mutagenesis of protein phosphatase 4 | 1FJM | A | 221SER | Increased Stability | Loss of E Act | 0.78 | 7.47 | None | Y | Both | Y | |

5 | Mutagenesis of protein phosphatase 5 | 1FJM | A | 95ALA | Increased Stability | Loss of E Act | 0.17 | 1.6 | None | Y | Both | Y | |

5 | Mutagenesis of protein phosphatase 6 | 1FJM | A | 208ALA | Increased Stability | Loss of E Act | -0.23 | -2.14 | None | N | Both | N | |

6 | Antifungal activity of a rice lipid transfer protein | 1FK1 | A | 45ALA | Increased Stability | Loss of E Act | 3.46 | 51.78 | None | Y | Both | Y | |

6 | Antifungal activity of a rice lipid transfer protein | 1FK1 | A | 46ALA | Decreased Stability | NA | 2.33 | 18.24 | None | N | |||

6 | Antifungal activity of a rice lipid transfer protein | 1FK1 | A | 72LEU | Increased Stability | Loss of E Act | 5.83 | 35.16 | None | Y | Both | Y | |

7 | C-Reactive Protein Mutants and Pneumococcal Infection of mice | 1GNH | A | 114ALA | NA | Increased Activity | -0.37 | 28.93 | None | Y | |||

7 | C-Reactive Protein Mutants and Pneumococcal Infection of mice | 1GNH | A | 175ALA | NA | Loss of E Act | 1.42 | -16.96 | None | Y | |||

8 | Mutagenesis of hydroxysteroid dehyrogenase | 1HXH | A | 12ALA | NA | Loss of E Act | -0.49 | -3.17 | None | N | Enzyme | N | |

8 | Mutagenesis of hydroxysteroid dehyrogenase | 1HXH | A | 87ALA | Increased Stability | Loss of E Act | 5.93 | 40.78 | None | Y | Both | Y | |

8 | Mutagenesis of hydroxysteroid dehyrogenase | 1HXH | A | 138ALA | NA | Loss of E Act | 0.03 | 0.18 | None | Y | Enzyme | Y | |

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 83H | NA | Loss of E Act | 2.34 | 45.16 | None | Y | Enzyme | Y | |

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 147H | NA | Loss of E Act | 2.56 | 48.13 | None | Y | Enzyme | Y | |

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 136H | Decreased Stability | NA | -2.08 | -22.58 | None | Y | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 138H | Decreased Stability | NA | -7.94 | -37.53 | None | Y | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 139H | Decreased Stability | NA | -2.86 | -33.92 | None | Y | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 140H | Decreased Stability | NA | -1.41 | -20.25 | None | Y | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 141H | Decreased Stability | NA | -1.66 | -24.82 | None | Y | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 142H | Decreased Stability | NA | -0.39 | -3.24 | None | Y | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 143H | Decreased Stability | NA | -0.63 | -12.06 | None | Y | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 144H | Decreased Stability | NA | -1.25 | -29.07 | None | Y | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 145H | Decreased Stability | NA | -1.46 | -15.34 | None | Y | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 146H | Decreased Stability | NA | -2.14 | -19.5 | None | Y | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 148H | Decreased Stability | NA | 0.29 | 3.25 | None | N | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 149H | Decreased Stability | NA | -3.25 | -15.52 | None | Y | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 150H | Decreased Stability | NA | -4.26 | -32.48 | None | Y | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 151H | Decreased Stability | NA | -1.34 | -14.94 | None | Y | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 152H | Decreased Stability | NA | -0.11 | -12.3 | None | Y | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 153H | Decreased Stability | NA | -8.63 | -33.18 | None | Y | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 154H | Decreased Stability | NA | -0.11 | -1.43 | None | Y | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 155H | Decreased Stability | NA | -0.83 | -10.17 | None | Y | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 82H | Decreased Stability | NA | -0.48 | -12.79 | None | Y | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 84H | Decreased Stability | NA | -5.35 | -28.89 | None | Y | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 85H | Decreased Stability | NA | 1.36 | 19.29 | None | N | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 86H | Decreased Stability | NA | -2.64 | -32.39 | None | Y | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 87H | Decreased Stability | NA | -3.78 | -19.86 | None | Y | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 88H | Decreased Stability | NA | -3.92 | -23.66 | None | Y | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 89H | Decreased Stability | NA | -1.34 | -21.57 | None | Y | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 91H | Decreased Stability | NA | -3.96 | -21.88 | None | Y | |||

9 | Correlation Between Protein Binding Strength | 1L22 | _ | 92H | Decreased Stability | NA | 0.52 | 6.18 | None | N | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 2GLY | Decreased Stability | NA | -0.67 | -10.28 | CITED | Y | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 2ALA | Decreased Stability | NA | -0.51 | -7.75 | CITED | Y | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 2ILE | Increased Stability | NA | 0.58 | 8.92 | CITED | Y | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 2LEU | Decreased Stability | NA | -0.08 | -1.26 | CITED | Y | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 2MET | Decreased Stability | NA | -0.15 | -2.24 | CITED | Y | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 2PHE | Decreased Stability | NA | -2.3 | -35.09 | CITED | Y | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 2SER | Decreased Stability | NA | -0.65 | -9.89 | CITED | Y | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 2TYR | Decreased Stability | NA | -1.04 | -15.88 | CITED | Y | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 2ASP | Decreased Stability | NA | -1.26 | -19.21 | CITED | Y | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 2ASN | Decreased Stability | NA | -0.82 | -12.48 | CITED | Y | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 2ARG | Decreased Stability | NA | -2.29 | -34.96 | CITED | Y | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 74GLY | Decreased Stability | NA | -0.46 | -5.62 | CITED | Y | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 74ALA | Decreased Stability | NA | -0.44 | -5.39 | CITED | Y | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 74ILE | Increased Stability | NA | -0.78 | -9.57 | CITED | N | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 74LEU | Increased Stability | NA | -0.21 | -2.53 | CITED | N | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 74MET | Increased Stability | NA | -0.42 | -5.15 | CITED | N | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 74PHE | Decreased Stability | NA | 0.43 | 5.29 | CITED | N | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 74SER | Decreased Stability | NA | -0.66 | -8.19 | CITED | Y | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 74TYR | Decreased Stability | NA | -0.27 | -3.31 | CITED | Y | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 74ASP | Decreased Stability | NA | -1.75 | -21.58 | CITED | Y | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 74ASN | Decreased Stability | NA | -0.96 | -11.86 | CITED | Y | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 74ARG | Decreased Stability | NA | -1.34 | -16.54 | CITED | Y | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 110GLY | Increased Stability | NA | 0.01 | 0.32 | CITED | Y | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 110ALA | Increased Stability | NA | 0.6 | 15.73 | CITED | Y | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 110ILE | Increased Stability | NA | 0.04 | 1.1 | CITED | Y | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 110LEU | Increased Stability | NA | -0.33 | -8.52 | CITED | N | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 110MET | Increased Stability | NA | -0.46 | -11.93 | CITED | N | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 110PHE | Decreased Stability | NA | 0.47 | 12.32 | CITED | N | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 110TYR | Decreased Stability | NA | 0.22 | 5.82 | CITED | N | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 110ASP | Increased Stability | NA | 0.75 | 19.44 | CITED | Y | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 110ASN | Increased Stability | NA | 0.06 | 1.59 | CITED | Y | |||

10 | Surface Hydration and stability in lysozyme | 1LZ1 | _ | 110ARG | Increased Stability | NA | 1.79 | 46.67 | CITED | Y | |||

11 | N-terminal residues and conformational stability of human lysozyme | 1LZ1 | _ | 1MET | Decreased Stability | NA | 0.92 | 19.46 | CITED | N | |||

11 | N-terminal residues and conformational stability of human lysozyme | 1LZ1 | _ | 1ALA | Decreased Stability | NA | 0.82 | 17.29 | CITED | N | |||

12 | Mutagensis of Glucanase | 1MAC | A | 101PHE | NA | Loss of E Act | -1.04 | -16.03 | None | N | Enzyme | N | |

12 | Mutagensis of Glucanase | 1MAC | A | 101TYR | NA | Loss of E Act | 0.26 | 3.99 | None | Y | Enzyme | Y | |

12 | Mutagensis of Glucanase | 1MAC | A | 103ASP | NA | Loss of E Act | -0.12 | -1.41 | None | N | Enzyme | N | |

12 | Mutagensis of Glucanase | 1MAC | A | 103GLN | NA | Loss of E Act | 1.37 | 16.81 | None | Y | Enzyme | Y | |

12 | Mutagensis of Glucanase | 1MAC | A | 105ASN | NA | Loss of E Act | 1.86 | 16.07 | None | Y | Enzyme | Y | |

12 | Mutagensis of Glucanase | 1MAC | A | 105LYS | NA | Loss of E Act | 1.28 | 11.04 | None | Y | Enzyme | Y | |

12 | Mutagensis of Glucanase | 1MAC | A | 107ASP | NA | Loss of E Act | 0.51 | 3.41 | None | Y | Enzyme | Y | |

13 | Mutations and stability of methylamine dehydrogenase | 1MAE | L | 76ASN | Increased Stability | NA | 0.93 | 5.88 | None | Y | |||

13 | Mutations and stability of methylamine dehydrogenase | 1MAE | L | 122ALA | Increased Stability | NA | 0.44 | 1.38 | None | Y | |||

13 | Mutations and stability of methylamine dehydrogenase | 1MAE | L | 122CYS | Increased Stability | NA | 6.6 | 31.44 | None | Y | |||

13 | Mutations and stability of methylamine dehydrogenase | 1MAE | L | 119PHE | Decreased Stability | NA | -2.62 | -9.29 | None | Y | |||

13 | Mutations and stability of methylamine dehydrogenase | 1MAE | L | 119GLU | Increased Stability | NA | -9.85 | -60.46 | None | N | |||

13 | Mutations and stability of methylamine dehydrogenase | 1MAE | L | 119LYS | Increased Stability | NA | -5.89 | -40.21 | None | N | |||

14 | Human acid-Beta glucosidase and Gaucher disease | 1OGS | A | 370SER | Increased Stability | Loss of E Act | 2.28 | 15.44 | None | Y | Both | Y | |

14 | Human acid-Beta glucosidase and Gaucher disease | 1OGS | A | 394LEU | Increased Stability | Loss of E Act | -1.12 | -12.53 | None | N | Both | N | |

14 | Human acid-Beta glucosidase and Gaucher disease | 1OGS | A | 463CYS | Increased Stability | Loss of E Act | -1.16 | -15.39 | None | N | Both | N | |

14 | Human acid-Beta glucosidase and Gaucher disease | 1OGS | A | 469HIS | Increased Stability | Loss of E Act | 0.22 | 2.15 | None | Y | Both | Y | |

15 | Thermostabilization of an Enzyme | 1OX7 | A | 23LEU/140LEU/108ILE | Increased Stability | NA | 1.85 | 5.98 | None | Y | |||

15 | Thermostabilization of an Enzyme | 1OX7 | A | 23LEU/140LEU | Increased Stability | NA | 1.85 | 10.44 | None | Y | |||

15 | Thermostabilization of an Enzyme | 1OX7 | A | 23LEU | Increased Stability | NA | -0.65 | -5.62 | None | N | |||

15 | Thermostabilization of an Enzyme | 1OX7 | A | 140LEU | Increased Stability | NA | 2.21 | 13.91 | None | Y | |||

15 | Thermostabilization of an Enzyme | 1OX7 | A | 10THR | Increased Stability | NA | 0.8 | 15.43 | None | Y | |||

15 | Thermostabilization of an Enzyme | 1OX7 | A | 67GLU | Increased Stability | NA | -4.46 | -37.32 | None | N | |||

15 | Thermostabilization of an Enzyme | 1OX7 | A | 69LEU | Increased Stability | NA | 3.34 | 56.77 | None | Y | |||

16 | Structures of the mutants of prophobilinogen deaminase | 1PDA | _ | 26HIS | NA | Loss of E Act | 2.38 | 38.13 | None | Y | Enzyme | Y | |

16 | Structures of the mutants of prophobilinogen deaminase | 1PDA | _ | 31THR | Decreased Stability | NA | -0.49 | -5.75 | None | Y | |||

16 | Structures of the mutants of prophobilinogen deaminase | 1PDA | _ | 34LYS | Decreased Stability | NA | -9.48 | -48.4 | None | Y | |||

16 | Structures of the mutants of prophobilinogen deaminase | 1PDA | _ | 93PHE | Decreased Stability | NA | 0.42 | 4.55 | None | N | |||

16 | Structures of the mutants of prophobilinogen deaminase | 1PDA | _ | 116THR | Decreased Stability | NA | -10.14 | -32.93 | None | Y | |||

16 | Structures of the mutants of prophobilinogen deaminase | 1PDA | _ | 116TRP | Decreased Stability | NA | -2.63 | -8.53 | None | Y | |||

16 | Structures of the mutants of prophobilinogen deaminase | 1PDA | _ | 116GLN | Decreased Stability | NA | -13.43 | -43.63 | None | Y | |||

16 | Structures of the mutants of prophobilinogen deaminase | 1PDA | _ | 149LEU | Decreased Stability | NA | 2.48 | 29.38 | None | N | |||

16 | Structures of the mutants of prophobilinogen deaminase | 1PDA | _ | 167TRP | NA | Loss of E Act | -2.49 | -13.28 | None | N | Enzyme | N | |

16 | Structures of the mutants of prophobilinogen deaminase | 1PDA | _ | 173TRP | NA | Loss of E Act | 2 | 13.85 | None | Y | Enzyme | Y | |

16 | Structures of the mutants of prophobilinogen deaminase | 1PDA | _ | 177ARG | Decreased Stability | NA | -3.8 | -34.31 | None | Y | |||

16 | Structures of the mutants of prophobilinogen deaminase | 1PDA | _ | 201TRP | Decreased Stability | NA | 0.63 | 3.63 | None | N | |||

16 | Structures of the mutants of prophobilinogen deaminase | 1PDA | _ | 223LYS | Decreased Stability | NA | -1.63 | -20.13 | None | Y | |||

16 | Structures of the mutants of prophobilinogen deaminase | 1PDA | _ | 247PHE | Decreased Stability | NA | 2.62 | 20.81 | None | N | |||

16 | Structures of the mutants of prophobilinogen deaminase | 1PDA | _ | 250LYS | Decreased Stability | NA | -3.11 | -28.24 | None | Y | |||

16 | Structures of the mutants of prophobilinogen deaminase | 1PDA | _ | 252THR | Decreased Stability | NA | -1.03 | -9.02 | None | Y | |||

16 | Structures of the mutants of prophobilinogen deaminase | 1PDA | _ | 256ASN | Decreased Stability | NA | 0.24 | 3.31 | None | N | |||

17 | Alanine insertion in lactose permease transmembrane helices | 1PV7 | A | 79ALA | Decreased Stability | NA | 2.61 | 15.6 | None | N | |||

17 | Alanine insertion in lactose permease transmembrane helices | 1PV7 | A | 83ALA | Decreased Stability | NA | -2.93 | -16.58 | None | Y | |||

17 | Alanine insertion in lactose permease transmembrane helices | 1PV7 | A | 87ALA | Decreased Stability | NA | -4.82 | -17.13 | None | Y | |||

17 | Alanine insertion in lactose permease transmembrane helices | 1PV7 | A | 96ALA | Decreased Stability | NA | 1.72 | 14.84 | None | N | |||

17 | Alanine insertion in lactose permease transmembrane helices | 1PV7 | A | 90ALA | Decreased Stability | NA | -2.11 | -10.94 | None | Y | |||

17 | Alanine insertion in lactose permease transmembrane helices | 1PV7 | A | 91ALA | Decreased Stability | NA | -3.79 | -15.98 | None | Y | |||

17 | Alanine insertion in lactose permease transmembrane helices | 1PV7 | A | 93ALA | Decreased Stability | NA | -0.38 | -8.7 | None | Y | |||

18 | Disulfide bonds and stability of acetylcholinesterase | 1QO9 | A | 327CYS/375CYS | Increased Stability | NA | 7.77 | 34.06 | None | Y | |||

18 | Disulfide bonds and stability of acetylcholinesterase | 1QO9 | A | 354CYS/456CYS | Increased Stability | NA | 1.36 | 4.74 | None | Y | |||

18 | Disulfide bonds and stability of acetylcholinesterase | 1QO9 | A | 369CYS/476CYS | Increased Stability | NA | 1.82 | 9.56 | None | Y | |||

18 | Disulfide bonds and stability of acetylcholinesterase | 1QO9 | A | 452CYS/533CYS | Decreased Stability | NA | 1.51 | 11.14 | None | N | |||

18 | Disulfide bonds and stability of acetylcholinesterase | 1QO9 | A | 464CYS/543CYS | Increased Stability | NA | 2.82 | 22.11 | None | Y | |||

19 | Stabilizing mutations in subtilisin BPN | 1SBT | _ | 41ALA/50PHE/73LEU/206TRP/217LYS/218SER/221CYS/271GLU | Increased Stability | NA | 2.39 | 3.11 | None | Y | |||

19 | Stabilizing mutations in subtilisin BPN | 1SBT | _ | 2LYS/3CYS/5SER/43ASN/50PHE/73LEU/206CYS/217LYS/218SER/271GLU | Increased Stability | NA | 2.57 | 3.13 | None | Y | |||

20 | Salt Bridges and stability of subtilisin BPN | 1SBT | _ | 271GLU | Decreased Stability | NA | -0.1 | -1.42 | None | Y | |||

20 | Salt Bridges and stability of subtilisin BPN | 1SBT | _ | 51LYS | Decreased Stability | NA | -3.37 | -35.21 | None | Y | |||

20 | Salt Bridges and stability of subtilisin BPN | 1SBT | _ | 164ARG | Decreased Stability | NA | -2.44 | -21.27 | None | Y | |||

21 | Mutagenesis of the unfolding region of ribonuclease A | 2AAS | _ | 35SER | Decreased Stability | NA | -1.04 | -15.73 | None | Y | |||

21 | Mutagenesis of the unfolding region of ribonuclease A | 2AAS | _ | 35ALA | Decreased Stability | NA | -1.53 | -8.02 | None | Y | |||

21 | Mutagenesis of the unfolding region of ribonuclease A | 2AAS | _ | 46TYR | Decreased Stability | NA | -0.85 | -4.11 | None | Y | |||

21 | Mutagenesis of the unfolding region of ribonuclease A | 2AAS | _ | 31ALA/33SER | Decreased Stability | NA | 8.74 | 69.54 | None | N | |||

21 | Mutagenesis of the unfolding region of ribonuclease A | 2AAS | _ | 35SER/46TYR | Decreased Stability | NA | -1.08 | -4.38 | None | Y | |||

21 | Mutagenesis of the unfolding region of ribonuclease A | 2AAS | _ | 35ALA/46TYR | Decreased Stability | NA | -1.21 | -4.93 | None | Y | |||

21 | Mutagenesis of the unfolding region of ribonuclease A | 2AAS | _ | 31ALA/33SER/46TYR | Decreased Stability | NA | 7.64 | 25.91 | None | N | |||

22 | Radical stability in ribonucleotide reductase from E-coli | 2ALX | A | 212TRP | Decreased Stability | NA | -1.62 | -7.52 | None | Y | |||

22 | Radical stability in ribonucleotide reductase from E-coli | 2ALX | A | 234ASN | Decreased Stability | NA | -5.41 | -34.1 | None | Y | |||

23 | Evolutionally conserved aspartic acid residues in human glutathione | 6GSS | A | 57ALA | Decreased Stability | NA | 2.54 | 27.26 | None | N | |||

23 | Evolutionally conserved aspartic acid residues in human glutathione | 6GSS | A | 98ALA | Decreased Stability | NA | 1.07 | 16.61 | None | N | |||

23 | Evolutionally conserved aspartic acid residues in human glutathione | 6GSS | A | 152ALA | Decreased Stability | NA | 5.17 | 43.54 | None | N | |||

24 | Hydrophobic core mutations and stability | 1B2X | A | 14ALA | Decreased Stability | NA | -3.07 | -12.62 | None | Y | |||

24 | Hydrophobic core mutations and stability | 1B2X | A | 51VAL | Decreased Stability | NA | -0.28 | -2.46 | None | Y | |||

24 | Hydrophobic core mutations and stability | 1B2X | A | 76ALA | Decreased Stability | NA | -2.22 | -12.78 | None | Y | |||

24 | Hydrophobic core mutations and stability | 1B2X | A | 76VAL | Decreased Stability | NA | 0.46 | 2.67 | None | N | |||

24 | Hydrophobic core mutations and stability | 1B2X | A | 88ALA | Decreased Stability | NA | -4.83 | -18.47 | None | Y | |||

24 | Hydrophobic core mutations and stability | 1B2X | A | 88VAL | Decreased Stability | NA | -1.29 | -4.93 | None | Y | |||

24 | Hydrophobic core mutations and stability | 1B2X | A | 89VAL | Decreased Stability | NA | -0.79 | -3.08 | None | Y | |||

24 | Hydrophobic core mutations and stability | 1B2X | A | 96ALA | Decreased Stability | NA | -2.55 | -13.76 | None | Y | |||

24 | Hydrophobic core mutations and stability | 1B2X | A | 96VAL | Decreased Stability | NA | -1.05 | -5.65 | None | Y | |||

24 | Hydrophobic core mutations and stability | 2CI2 | I | 39VAL | Decreased Stability | NA | -0.46 | -2.3 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 2CI2 | I | 48ALA | Decreased Stability | NA | -1.99 | -16.42 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 2CI2 | I | 48VAL | Decreased Stability | NA | -0.44 | -3.62 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 2CI2 | I | 48ALA/76VAL | Decreased Stability | NA | -2.18 | -7.57 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 2CI2 | I | 66ALA | Decreased Stability | NA | -2.44 | -13.86 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 2CI2 | I | 68ALA | Decreased Stability | NA | -2.66 | -13.34 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 2CI2 | I | 70ALA | Decreased Stability | NA | -1.87 | -11.79 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 2CI2 | I | 76VAL | Decreased Stability | NA | -0.19 | -1.15 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 2CI2 | I | 76ALA | Decreased Stability | NA | -2.14 | -12.81 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1EY0 | A | 141ALA | Decreased Stability | NA | 0.25 | 5.8 | None | N | |||

24 | Hydrophobic core mutations and stability | 1EY0 | A | 99ALA | Decreased Stability | NA | -4.18 | -18.84 | None | Y | |||

24 | Hydrophobic core mutations and stability | 1EY0 | A | 74ALA | Decreased Stability | NA | -3.33 | -14.52 | None | Y | |||

24 | Hydrophobic core mutations and stability | 1EY0 | A | 72VAL | Decreased Stability | NA | -0.19 | -0.81 | None | Y | |||

24 | Hydrophobic core mutations and stability | 1EY0 | A | 34ALA | Decreased Stability | NA | -4.19 | -17.33 | None | Y | |||

24 | Hydrophobic core mutations and stability | 1EY0 | A | 66ALA | Decreased Stability | NA | -3.76 | -13.94 | None | Y | |||

24 | Hydrophobic core mutations and stability | 1EY0 | A | 23ALA | Decreased Stability | NA | -4.55 | -15.23 | None | Y | |||

24 | Hydrophobic core mutations and stability | 1EY0 | A | 25ALA | Decreased Stability | NA | -4.35 | -14.28 | None | Y | |||

24 | Hydrophobic core mutations and stability | 1EY0 | A | 92VAL | Decreased Stability | NA | -1.32 | -4.29 | None | Y | |||

24 | Hydrophobic core mutations and stability | 1EY0 | A | 92ALA | Decreased Stability | NA | -6.1 | -19.78 | None | Y | |||

24 | Hydrophobic core mutations and stability | 1EY0 | A | 36ALA | Decreased Stability | NA | -1.97 | -10.39 | None | Y | |||

24 | Hydrophobic core mutations and stability | 1EY0 | A | 72VAL/113ALA | Decreased Stability | NA | 0 | 0.01 | None | N | |||

24 | Hydrophobic core mutations and stability | 1EY0 | A | 72VAL/85ALA | Decreased Stability | NA | -0.64 | -2.37 | None | Y | |||

24 | Hydrophobic core mutations and stability | 1EY0 | A | 66LEU | Decreased Stability | NA | 0.33 | 1.22 | None | N | |||

24 | Hydrophobic core mutations and stability | 1EY0 | A | 23PHE | Decreased Stability | NA | -0.15 | -0.49 | None | Y | |||

24 | Hydrophobic core mutations and stability | 1EY0 | A | 117GLY/124LEU/128ALA | Increased Stability | NA | 5.04 | 27.08 | None | Y | |||

24 | Hydrophobic core mutations and stability | 1EY0 | A | 41ILE/117GLY/124LEU/128ALA | Increased Stability | NA | 6.7 | 23.12 | None | Y | |||

24 | Hydrophobic core mutations and stability | 1EY0 | A | 33VAL/41ILE/117GLY/124LEU/128 ALA | Increased Stability | NA | 7.71 | 19.81 | None | Y | |||

24 | Hydrophobic core mutations and stability | 1EY0 | A | 41ILE/59ALA/117GLY/124LEU/128ALA | Increased Stability | NA | 7.68 | 20.54 | None | Y | |||

24 | Hydrophobic core mutations and stability | 1IGV | A | 6VAL | Decreased Stability | NA | 0.01 | 0.08 | CITED | N | |||

24 | Hydrophobic core mutations and stability | 1IGV | A | 23ALA | Decreased Stability | NA | -3.45 | -18.86 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1IGV | A | 28ALA | Decreased Stability | NA | -5.02 | -19.84 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1IGV | A | 61ALA | Decreased Stability | NA | -1.57 | -9.12 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1IGV | A | 66TRP | Decreased Stability | NA | -2.94 | -9.53 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1IGV | A | 66ALA | Decreased Stability | NA | -4.48 | -14.51 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1IGV | A | 70LEU | Decreased Stability | NA | 1.69 | 8.08 | CITED | N | |||

24 | Hydrophobic core mutations and stability | 1IGV | A | 73VAL | Decreased Stability | NA | -0.29 | -1.8 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1IGV | A | 10ALA | Decreased Stability | NA | -1.9 | -10.07 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 46 ALA | Decreased Stability | NA | -4.05 | -16.76 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 71 ILE | Decreased Stability | NA | 0.78 | 4.33 | CITED | N | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 71 MET | Decreased Stability | NA | -2.23 | -9.5 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 71 PHE | Decreased Stability | NA | -0.95 | -3.81 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 99 ALA | Decreased Stability | NA | -5.17 | -15.6 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 100 ALA | Decreased Stability | NA | -3.13 | -13.99 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 118 ALA | Decreased Stability | NA | -3.7 | -13.68 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 121 ALA | Decreased Stability | NA | -6.6 | -22.66 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 133 ALA | Decreased Stability | NA | -0.48 | -8.43 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 153 VAL | Decreased Stability | NA | -0.87 | -3.47 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 153 MET | Decreased Stability | NA | -3.03 | -11.5 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 153 LEU | Increased Stability | NA | 0.31 | 1.15 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 153 ILE | Decreased Stability | NA | -0.53 | -2.1 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 153 ALA | Decreased Stability | NA | -5.04 | -19.4 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 17 ALA | Decreased Stability | NA | -3.61 | -25.01 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 27 ALA | Decreased Stability | NA | -4.05 | -19.97 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 50 ALA | Decreased Stability | NA | -1.71 | -15.41 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 58 ALA | Decreased Stability | NA | -4.13 | -22.66 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 78 ALA | Decreased Stability | NA | -2.28 | -14.34 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 87 ALA | Decreased Stability | NA | -1.81 | -9.31 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 103 ALA | Decreased Stability | NA | -2.15 | -11.79 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 111 ALA | Decreased Stability | NA | -2.32 | -12.8 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 67 ALA | Decreased Stability | NA | -2.48 | -17.62 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 104 ALA | Decreased Stability | NA | -2.68 | -17.46 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 66 ALA | Decreased Stability | NA | -2.75 | -14.38 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 84 ALA | Decreased Stability | NA | -3.23 | -17.26 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 91 ALA | Decreased Stability | NA | -2.74 | -15.61 | CITED | Y | |||

24 | Hydrophobic core mutations and stability | 1L63 | _ | 1 71 ALA | Decreased Stability | NA | -3.27 | -14.62 | CITED | Y | |||

80 CITED |