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Washington State University
Promotion Talk

Abelson 201
August 24, Monday, 4:00 - 5:00 PM


Elissa Schwartz

Department of Mathematics
Washington State University

Title: Modeling Infectious Disease Dynamics

Abstract: In this talk, I will discuss my research using mathematical modeling to delineate mechanisms of viral escape from inhibition and control. First I will focus on lentiviral infection.  In equine infectious anemia virus infection, deterministic modeling is used to elucidate the mechanisms of virus persistence and escape from the antibody response. In human immunodeficiency virus infection, agent-based modeling is used to investigate viral escape from the cellular immune response.  Next I will discuss models of the 2009 H1N1 influenza epidemic. Using models of the outbreak on our campus, the transmission rate and the vaccine efficacy for this particular epidemic were estimated.  Finally I will describe my establishment of a laboratory system for examining virus dynamics in vitro. Numerical simulations illustrate my research contributions in each area, which are part of an integrated research agenda targeted towards understanding viral escape from inhibition.