Reference # Publication PDB Mutation(s) Change in Stability Change in Activity Prediction Percentage Change Protherm Statusge�������������������������������������������������������������������������������������� Correct Total Total Enzyme Non Enzyme Total
1 Disulfide bond-deficient azurin mutant 1AZU 3ALA/26ALA Decreased Stability NA -4.45921 -22.53 None Y 237 Correct Correct
1 Disulfide bond-deficient azurin mutant 1AZU 3ALA/26ILE Decreased Stability NA -3.18862 -16.11 None Y 17 169
1 Disulfide bond-deficient azurin mutant 1AZU 3ALA/25ARG/26ALA/27ARG Decreased Stability NA -5.2459 -24.17 None Y Total Correct Incorrect Incorrect
2 In-vitro selection of highly stabilized mutants 1CSQ 66LEU/67PRO Increased Stability NA 0.336951 4.625 None Y 186 10 41
2 In-vitro selection of highly stabilized mutants 1CSQ 2ILE/3SER/46GLN/64LEU/66LEU/67PRO Increased Stability NA 0.598095 2.099 None Y Percentage Percentage
2 In-vitro selection of highly stabilized mutants 1CSQ 46LEU/66LEU/67HIS Increased Stability NA 0.577069 4.823 None Y Total Incorrect 62.96% 80.48%
2 In-vitro selection of highly stabilized mutants 1CSQ 2TYR/3ARG/46LEU Increased Stability NA 0.664795 3.696 None Y 51
2 In-vitro selection of highly stabilized mutants 1CSQ 2TYR/3ILE/46GLN/64LEU/66LEU/67PRO Increased Stability NA 0.992685 4.028 None Y
3 Contribution of tryptophan to the properties of ribotoxin  -sarcin 1DE3 4PHE Decreased Stability NA 2.8877 16.25 None N Total Percentage
3 Contribution of tryptophan to the properties of ribotoxin  -sarcin 1DE3 51PHE Decreased Stability NA 0.919951 7.762 None N 77.97%
3 Contribution of tryptophan to the properties of ribotoxin  -sarcin 1DE3 4PHE/51PHE Decreased Stability NA 3.20872 12.37 None N
4 Reduction of hydrophobicity in bacteriorhodopsin 1DZE 113GLN Decreased Stability NA -0.256076 -2.575 None Y
4 Reduction of hydrophobicity in bacteriorhodopsin 1DZE 113GLN/116GLN Decreased Stability NA -0.703292 -4.642 None Y
4 Reduction of hydrophobicity in bacteriorhodopsin 1DZE 113GLN/116GLN/120GLN Decreased Stability NA -1.01573 -4.609 None Y
4 Reduction of hydrophobicity in bacteriorhodopsin 1DZE 113GLN/116GLN/120GLN/124GLN Decreased Stability NA -1.71383 -5.915 None Y
4 Reduction of hydrophobicity in bacteriorhodopsin 1DZE 113GLN/116GLN/117ASP/120GLN/124GLN Decreased Stability NA -6.72536 -19.42 None Y
5 Mutagenesis of protein phosphatase 1 1FJM 124ASP Increased Stability Loss of E Act -0.222354 -1.472 None N Both N
5 Mutagenesis of protein phosphatase 2 1FJM 248ASN Increased Stability Loss of E Act -6.39998 -28.49 None N Both N
5 Mutagenesis of protein phosphatase 3 1FJM 96ALA Increased Stability Loss of E Act -0.303251 -3.225 None N Both N
5 Mutagenesis of protein phosphatase 4 1FJM 221SER Increased Stability Loss of E Act 0.775202 7.469 None Y Both Y
5 Mutagenesis of protein phosphatase 5 1FJM 95ALA Increased Stability Loss of E Act 0.173728 1.603 None Y Both Y
5 Mutagenesis of protein phosphatase 6 1FJM 208ALA Increased Stability Loss of E Act -0.227142 -2.138 None N Both N
6 Antifungal activity of a rice lipid transfer protein 1FK1 45ALA Increased Stability Loss of E Act 3.45608 51.78 None Y Both Y
6 Antifungal activity of a rice lipid transfer protein 1FK1 46ALA Decreased Stability NA 2.333 18.24 None N
6 Antifungal activity of a rice lipid transfer protein 1FK1 72LEU Increased Stability Loss of E Act 5.83463 35.16 None Y Both Y
7 C-Reactive Protein Mutants and Pneumococcal Infection of mice 1GNH 114ALA NA Increased Activity -0.37 28.93 None Y
7 C-Reactive Protein Mutants and Pneumococcal Infection of mice 1GNH 175ALA NA Loss of E Act 1.42 -16.96 None Y
8 Mutagenesis of hydroxysteroid dehyrogenase 1HXH 12ALA NA Loss of E Act -0.49 -3.167 None N Enzyme N
8 Mutagenesis of hydroxysteroid dehyrogenase 1HXH 87ALA Increased Stability Loss of E Act 5.93 40.78 None Y Both Y
8 Mutagenesis of hydroxysteroid dehyrogenase 1HXH 138ALA NA Loss of E Act 0.0255558 0.1757 None Y Enzyme Y
9 Correlation Between Protein Binding Strength 1L22 83H NA Loss of E Act 2.33815 45.16 None Y Enzyme Y
9 Correlation Between Protein Binding Strength 1L22 147H NA Loss of E Act 2.56243 48.13 None Y Enzyme Y
9 Correlation Between Protein Binding Strength 1L22 136H Decreased Stability NA -2.08479 -22.58 None Y
9 Correlation Between Protein Binding Strength 1L22 138H Decreased Stability NA -7.93624 -37.53 None Y
9 Correlation Between Protein Binding Strength 1L22 139H Decreased Stability NA -2.86357 -33.92 None Y
9 Correlation Between Protein Binding Strength 1L22 140H Decreased Stability NA -1.41319 -20.25 None Y
9 Correlation Between Protein Binding Strength 1L22 141H Decreased Stability NA -1.65622 -24.82 None Y
9 Correlation Between Protein Binding Strength 1L22 142H Decreased Stability NA -0.39226 -3.244 None Y
9 Correlation Between Protein Binding Strength 1L22 143H Decreased Stability NA -0.63403 -12.06 None Y
9 Correlation Between Protein Binding Strength 1L22 144H Decreased Stability NA -1.25059 -29.07 None Y
9 Correlation Between Protein Binding Strength 1L22 145H Decreased Stability NA -1.45804 -15.34 None Y
9 Correlation Between Protein Binding Strength 1L22 146H Decreased Stability NA -2.14085 -19.5 None Y
9 Correlation Between Protein Binding Strength 1L22 148H Decreased Stability NA 0.28712 3.249 None N
9 Correlation Between Protein Binding Strength 1L22 149H Decreased Stability NA -3.24788 -15.52 None Y
9 Correlation Between Protein Binding Strength 1L22 150H Decreased Stability NA -4.2589 -32.48 None Y
9 Correlation Between Protein Binding Strength 1L22 151H Decreased Stability NA -1.34497 -14.94 None Y
9 Correlation Between Protein Binding Strength 1L22 152H Decreased Stability NA -0.110675 -12.3 None Y
9 Correlation Between Protein Binding Strength 1L22 153H Decreased Stability NA -8.63491 -33.18 None Y
9 Correlation Between Protein Binding Strength 1L22 154H Decreased Stability NA -0.110675 -1.428 None Y
9 Correlation Between Protein Binding Strength 1L22 155H Decreased Stability NA -0.825214 -10.17 None Y
9 Correlation Between Protein Binding Strength 1L22 82H Decreased Stability NA -0.475054 -12.79 None Y
9 Correlation Between Protein Binding Strength 1L22 84H Decreased Stability NA -5.35203 -28.89 None Y
9 Correlation Between Protein Binding Strength 1L22 85H Decreased Stability NA 1.36018 19.29 None N
9 Correlation Between Protein Binding Strength 1L22 86H Decreased Stability NA -2.63642 -32.39 None Y
9 Correlation Between Protein Binding Strength 1L22 87H Decreased Stability NA -3.78448 -19.86 None Y
9 Correlation Between Protein Binding Strength 1L22 88H Decreased Stability NA -3.92167 -23.66 None Y
9 Correlation Between Protein Binding Strength 1L22 89H Decreased Stability NA -1.34147 -21.57 None Y
9 Correlation Between Protein Binding Strength 1L22 91H Decreased Stability NA -3.96076 -21.88 None Y
9 Correlation Between Protein Binding Strength 1L22 92H Decreased Stability NA 0.52197 6.184 None N
10 Surface Hydration and stability in lysozyme 1LZ1 2GLY Decreased Stability NA -0.674015 -10.28 CITED Y
10 Surface Hydration and stability in lysozyme 1LZ1 2ALA Decreased Stability NA -0.508228 -7.752 CITED Y
10 Surface Hydration and stability in lysozyme 1LZ1 2ILE Increased Stability NA 0.584538 8.916 CITED Y
10 Surface Hydration and stability in lysozyme 1LZ1 2LEU Decreased Stability NA -0.0826045 -1.26 CITED Y
10 Surface Hydration and stability in lysozyme 1LZ1 2MET Decreased Stability NA -0.146948 -2.241 CITED Y
10 Surface Hydration and stability in lysozyme 1LZ1 2PHE Decreased Stability NA -2.30051 -35.09 CITED Y
10 Surface Hydration and stability in lysozyme 1LZ1 2SER Decreased Stability NA -0.648123 -9.886 CITED Y
10 Surface Hydration and stability in lysozyme 1LZ1 2TYR Decreased Stability NA -1.04121 -15.88 CITED Y
10 Surface Hydration and stability in lysozyme 1LZ1 2ASP Decreased Stability NA -1.25947 -19.21 CITED Y
10 Surface Hydration and stability in lysozyme 1LZ1 2ASN Decreased Stability NA -0.818539 -12.48 CITED Y
10 Surface Hydration and stability in lysozyme 1LZ1 2ARG Decreased Stability NA -2.29184 -34.96 CITED Y
10 Surface Hydration and stability in lysozyme 1LZ1 74GLY Decreased Stability NA -0.456838 -5.624 CITED Y
10 Surface Hydration and stability in lysozyme 1LZ1 74ALA Decreased Stability NA -0.437579 -5.387 CITED Y
10 Surface Hydration and stability in lysozyme 1LZ1 74ILE Increased Stability NA -0.777044 -9.566 CITED N
10 Surface Hydration and stability in lysozyme 1LZ1 74LEU Increased Stability NA -0.205463 -2.529 CITED N
10 Surface Hydration and stability in lysozyme 1LZ1 74MET Increased Stability NA -0.418553 -5.153 CITED N
10 Surface Hydration and stability in lysozyme 1LZ1 74PHE Decreased Stability NA 0.429848 5.292 CITED N
10 Surface Hydration and stability in lysozyme 1LZ1 74SER Decreased Stability NA -0.664867 -8.185 CITED Y
10 Surface Hydration and stability in lysozyme 1LZ1 74TYR Decreased Stability NA -0.268537 -3.306 CITED Y
10 Surface Hydration and stability in lysozyme 1LZ1 74ASP Decreased Stability NA -1.75328 -21.58 CITED Y
10 Surface Hydration and stability in lysozyme 1LZ1 74ASN Decreased Stability NA -0.963144 -11.86 CITED Y
10 Surface Hydration and stability in lysozyme 1LZ1 74ARG Decreased Stability NA -1.3433 -16.54 CITED Y
10 Surface Hydration and stability in lysozyme 1LZ1 110GLY Increased Stability NA 0.0123846 0.3229 CITED Y
10 Surface Hydration and stability in lysozyme 1LZ1 110ALA Increased Stability NA 0.603237 15.73 CITED Y
10 Surface Hydration and stability in lysozyme 1LZ1 110ILE Increased Stability NA 0.0420161 1.095 CITED Y
10 Surface Hydration and stability in lysozyme 1LZ1 110LEU Increased Stability NA -0.326839 -8.521 CITED N
10 Surface Hydration and stability in lysozyme 1LZ1 110MET Increased Stability NA -0.457562 -11.93 CITED N
10 Surface Hydration and stability in lysozyme 1LZ1 110PHE Decreased Stability NA 0.472663 12.32 CITED N
10 Surface Hydration and stability in lysozyme 1LZ1 110TYR Decreased Stability NA 0.22319 5.819 CITED N
10 Surface Hydration and stability in lysozyme 1LZ1 110ASP Increased Stability NA 0.74566 19.44 CITED Y
10 Surface Hydration and stability in lysozyme 1LZ1 110ASN Increased Stability NA 0.0609652 1.59 CITED Y
10 Surface Hydration and stability in lysozyme 1LZ1 110ARG Increased Stability NA 1.79004 46.67 CITED Y
11 N-terminal residues and conformational stability of human lysozyme 1LZ1 1MET Decreased Stability NA 0.924658 19.46 CITED N
11 N-terminal residues and conformational stability of human lysozyme 1LZ1 1ALA Decreased Stability NA 0.821548 17.29 CITED N
12 Mutagensis of Glucanase 1MAC 101PHE NA Loss of E Act -1.0392 -16.03 None N Enzyme N
12 Mutagensis of Glucanase 1MAC 101TYR NA Loss of E Act 0.258797 3.992 None Y Enzyme Y
12 Mutagensis of Glucanase 1MAC 103ASP NA Loss of E Act -0.115176 -1.409 None N Enzyme N
12 Mutagensis of Glucanase 1MAC 103GLN NA Loss of E Act 1.37429 16.81 None Y Enzyme Y
12 Mutagensis of Glucanase 1MAC 105ASN NA Loss of E Act 1.86418 16.07 None Y Enzyme Y
12 Mutagensis of Glucanase 1MAC 105LYS NA Loss of E Act 1.28087 11.04 None Y Enzyme Y
12 Mutagensis of Glucanase 1MAC 107ASP NA Loss of E Act 0.510309 3.408 None Y Enzyme Y
13 Mutations and stability of methylamine dehydrogenase 1MAE 76ASN Increased Stability NA 0.927076 5.875 None Y
13 Mutations and stability of methylamine dehydrogenase 1MAE 122ALA Increased Stability NA 0.43851 1.381 None Y
13 Mutations and stability of methylamine dehydrogenase 1MAE 122CYS Increased Stability NA 6.60024 31.44 None Y
13 Mutations and stability of methylamine dehydrogenase 1MAE 119PHE Decreased Stability NA -2.61749 -9.293 None Y
13 Mutations and stability of methylamine dehydrogenase 1MAE 119GLU Increased Stability NA -9.84733 -60.46 None N
13 Mutations and stability of methylamine dehydrogenase 1MAE 119LYS Increased Stability NA -5.88927 -40.21 None N
14 Human acid-Beta glucosidase and Gaucher disease 1OGS 370SER Increased Stability Loss of E Act 2.27942 15.44 None Y Both Y
14 Human acid-Beta glucosidase and Gaucher disease 1OGS 394LEU Increased Stability Loss of E Act -1.1243 -12.53 None N Both N
14 Human acid-Beta glucosidase and Gaucher disease 1OGS 463CYS Increased Stability Loss of E Act -1.16052 -15.39 None N Both N
14 Human acid-Beta glucosidase and Gaucher disease 1OGS 469HIS Increased Stability Loss of E Act 0.223954 2.154 None Y Both Y
15 Thermostabilization of an Enzyme 1OX7 23LEU/140LEU/108ILE Increased Stability NA 1.84675 5.976 None Y
15 Thermostabilization of an Enzyme 1OX7 23LEU/140LEU Increased Stability NA 1.8455 10.44 None Y
15 Thermostabilization of an Enzyme 1OX7 23LEU Increased Stability NA -0.649537 -5.624 None N
15 Thermostabilization of an Enzyme 1OX7 140LEU Increased Stability NA 2.21061 13.91 None Y
15 Thermostabilization of an Enzyme 1OX7 10THR Increased Stability NA 0.802092 15.43 None Y
15 Thermostabilization of an Enzyme 1OX7 67GLU Increased Stability NA -4.46313 -37.32 None N
15 Thermostabilization of an Enzyme 1OX7 69LEU Increased Stability NA 3.33675 56.77 None Y
16 Structures of the mutants of prophobilinogen deaminase 1PDA 26HIS NA Loss of E Act 2.37613 38.13 None Y Enzyme Y
16 Structures of the mutants of prophobilinogen deaminase 1PDA 31THR Decreased Stability NA -0.491499 -5.751 None Y
16 Structures of the mutants of prophobilinogen deaminase 1PDA 34LYS Decreased Stability NA -9.47774 -48.4 None Y
16 Structures of the mutants of prophobilinogen deaminase 1PDA 93PHE Decreased Stability NA 0.423457 4.554 None N
16 Structures of the mutants of prophobilinogen deaminase 1PDA 116THR Decreased Stability NA -10.138 -32.93 None Y
16 Structures of the mutants of prophobilinogen deaminase 1PDA 116TRP Decreased Stability NA -2.62757 -8.534 None Y
16 Structures of the mutants of prophobilinogen deaminase 1PDA 116GLN Decreased Stability NA -13.4344 -43.63 None Y
16 Structures of the mutants of prophobilinogen deaminase 1PDA 149LEU Decreased Stability NA 2.4763 29.38 None N
16 Structures of the mutants of prophobilinogen deaminase 1PDA 167TRP NA Loss of E Act -2.49469 -13.28 None N Enzyme N
16 Structures of the mutants of prophobilinogen deaminase 1PDA 173TRP NA Loss of E Act 1.99964 13.85 None Y Enzyme Y
16 Structures of the mutants of prophobilinogen deaminase 1PDA 177ARG Decreased Stability NA -3.80265 -34.31 None Y
16 Structures of the mutants of prophobilinogen deaminase 1PDA 201TRP Decreased Stability NA 0.629513 3.632 None N
16 Structures of the mutants of prophobilinogen deaminase 1PDA 223LYS Decreased Stability NA -1.62813 -20.13 None Y
16 Structures of the mutants of prophobilinogen deaminase 1PDA 247PHE Decreased Stability NA 2.6186 20.81 None N
16 Structures of the mutants of prophobilinogen deaminase 1PDA 250LYS Decreased Stability NA -3.1136 -28.24 None Y
16 Structures of the mutants of prophobilinogen deaminase 1PDA 252THR Decreased Stability NA -1.03385 -9.024 None Y
16 Structures of the mutants of prophobilinogen deaminase 1PDA 256ASN Decreased Stability NA 0.239064 3.307 None N
17 Alanine insertion in lactose permease transmembrane helices 1PV7 79ALA Decreased Stability NA 2.61 15.6 None N
17 Alanine insertion in lactose permease transmembrane helices 1PV7 83ALA Decreased Stability NA -2.92816 -16.58 None Y
17 Alanine insertion in lactose permease transmembrane helices 1PV7 87ALA Decreased Stability NA -4.82452 -17.13 None Y
17 Alanine insertion in lactose permease transmembrane helices 1PV7 96ALA Decreased Stability NA 1.72073 14.84 None N
17 Alanine insertion in lactose permease transmembrane helices 1PV7 90ALA Decreased Stability NA -2.11275 -10.94 None Y
17 Alanine insertion in lactose permease transmembrane helices 1PV7 91ALA Decreased Stability NA -3.79438 -15.98 None Y
17 Alanine insertion in lactose permease transmembrane helices 1PV7 93ALA Decreased Stability NA -0.379284 -8.699 None Y
18 Disulfide bonds and stability of acetylcholinesterase 1QO9 327CYS/375CYS Increased Stability NA 7.77262 34.06 None Y
18 Disulfide bonds and stability of acetylcholinesterase 1QO9 354CYS/456CYS Increased Stability NA 1.35686 4.737 None Y
18 Disulfide bonds and stability of acetylcholinesterase 1QO9 369CYS/476CYS Increased Stability NA 1.82389 9.564 None Y
18 Disulfide bonds and stability of acetylcholinesterase 1QO9 452CYS/533CYS Decreased Stability NA 1.50532 11.14 None N
18 Disulfide bonds and stability of acetylcholinesterase 1QO9 464CYS/543CYS Increased Stability NA 2.81576 22.11 None Y
19 Stabilizing mutations in subtilisin BPN 1SBT 41ALA/50PHE/73LEU/206TRP/217LYS/218SER/221CYS/271GLU Increased Stability NA 2.38598 3.111 None Y
19 Stabilizing mutations in subtilisin BPN 1SBT 2LYS/3CYS/5SER/43ASN/50PHE/73LEU/206CYS/217LYS/218SER/271GLU Increased Stability NA 2.57274 3.13 None Y
20 Salt Bridges and stability of subtilisin BPN 1SBT 271GLU Decreased Stability NA -0.103037 -1.422 None Y
20 Salt Bridges and stability of subtilisin BPN 1SBT 51LYS Decreased Stability NA -3.36579 -35.21 None Y
20 Salt Bridges and stability of subtilisin BPN 1SBT 164ARG Decreased Stability NA -2.43502 -21.27 None Y
21 Mutagenesis of the unfolding region of ribonuclease A 2AAS 35SER Decreased Stability NA -1.03759 -15.73 None Y
21 Mutagenesis of the unfolding region of ribonuclease A 2AAS 35ALA Decreased Stability NA -1.5288 -8.016 None Y
21 Mutagenesis of the unfolding region of ribonuclease A 2AAS 46TYR Decreased Stability NA -0.854175 -4.112 None Y
21 Mutagenesis of the unfolding region of ribonuclease A 2AAS 31ALA/33SER Decreased Stability NA 8.74232 69.54 None N
21 Mutagenesis of the unfolding region of ribonuclease A 2AAS 35SER/46TYR Decreased Stability NA -1.07805 -4.381 None Y
21 Mutagenesis of the unfolding region of ribonuclease A 2AAS 35ALA/46TYR Decreased Stability NA -1.21281 -4.929 None Y
21 Mutagenesis of the unfolding region of ribonuclease A 2AAS 31ALA/33SER/46TYR Decreased Stability NA 7.64359 25.91 None N
22 Radical stability in ribonucleotide reductase from E-coli 2ALX 212TRP Decreased Stability NA -1.61978 -7.524 None Y
22 Radical stability in ribonucleotide reductase from E-coli 2ALX 234ASN Decreased Stability NA -5.40628 -34.1 None Y
23 Evolutionally conserved aspartic acid residues in human glutathione 6GSS 57ALA Decreased Stability NA 2.53876 27.26 None N
23 Evolutionally conserved aspartic acid residues in human glutathione 6GSS 98ALA Decreased Stability NA 1.06901 16.61 None N
23 Evolutionally conserved aspartic acid residues in human glutathione 6GSS 152ALA Decreased Stability NA 5.17116 43.54 None N
24 Hydrophobic core mutations and stability 1B2X 14ALA Decreased Stability NA -3.07396 -12.62 None Y
24 Hydrophobic core mutations and stability 1B2X 51VAL Decreased Stability NA -0.284959 -2.46 None Y
24 Hydrophobic core mutations and stability 1B2X 76ALA Decreased Stability NA -2.22445 -12.78 None Y
24 Hydrophobic core mutations and stability 1B2X 76VAL Decreased Stability NA 0.463824 2.666 None N
24 Hydrophobic core mutations and stability 1B2X 88ALA Decreased Stability NA -4.82603 -18.47 None Y
24 Hydrophobic core mutations and stability 1B2X 88VAL Decreased Stability NA -1.28822 -4.93 None Y
24 Hydrophobic core mutations and stability 1B2X 89VAL Decreased Stability NA -0.791489 -3.079 None Y
24 Hydrophobic core mutations and stability 1B2X 96ALA Decreased Stability NA -2.55145 -13.76 None Y
24 Hydrophobic core mutations and stability 1B2X 96VAL Decreased Stability NA -1.04788 -5.652 None Y
24 Hydrophobic core mutations and stability 2CI2 39VAL Decreased Stability NA -0.459814 -2.298 CITED Y
24 Hydrophobic core mutations and stability 2CI2 48ALA Decreased Stability NA -1.99251 -16.42 CITED Y
24 Hydrophobic core mutations and stability 2CI2 48VAL Decreased Stability NA -0.439482 -3.622 CITED Y
24 Hydrophobic core mutations and stability 2CI2 48ALA/76VAL Decreased Stability NA -2.18381 -7.571 CITED Y
24 Hydrophobic core mutations and stability 2CI2 66ALA Decreased Stability NA -2.44054 -13.86 CITED Y
24 Hydrophobic core mutations and stability 2CI2 68ALA Decreased Stability NA -2.6584 -13.34 CITED Y
24 Hydrophobic core mutations and stability 2CI2 70ALA Decreased Stability NA -1.86839 -11.79 CITED Y
24 Hydrophobic core mutations and stability 2CI2 76VAL Decreased Stability NA -0.191302 -1.145 CITED Y
24 Hydrophobic core mutations and stability 2CI2 76ALA Decreased Stability NA -2.14036 -12.81 CITED Y
24 Hydrophobic core mutations and stability 1EY0 141ALA Decreased Stability NA 0.2488 5.8 None N
24 Hydrophobic core mutations and stability 1EY0 99ALA Decreased Stability NA -4.17964 -18.84 None Y
24 Hydrophobic core mutations and stability 1EY0 74ALA Decreased Stability NA -3.33248 -14.52 None Y
24 Hydrophobic core mutations and stability 1EY0 72VAL Decreased Stability NA -0.18658 -0.8078 None Y
24 Hydrophobic core mutations and stability 1EY0 34ALA Decreased Stability NA -4.18607 -17.33 None Y
24 Hydrophobic core mutations and stability 1EY0 66ALA Decreased Stability NA -3.76425 -13.94 None Y
24 Hydrophobic core mutations and stability 1EY0 23ALA Decreased Stability NA -4.55256 -15.23 None Y
24 Hydrophobic core mutations and stability 1EY0 25ALA Decreased Stability NA -4.35434 -14.28 None Y
24 Hydrophobic core mutations and stability 1EY0 92VAL Decreased Stability NA -1.32394 -4.289 None Y
24 Hydrophobic core mutations and stability 1EY0 92ALA Decreased Stability NA -6.10455 -19.78 None Y
24 Hydrophobic core mutations and stability 1EY0 36ALA Decreased Stability NA -1.97202 -10.39 None Y
24 Hydrophobic core mutations and stability 1EY0 72VAL/113ALA Decreased Stability NA 0.00330174 0.01228 None N
24 Hydrophobic core mutations and stability 1EY0 72VAL/85ALA Decreased Stability NA -0.638996 -2.366 None Y
24 Hydrophobic core mutations and stability 1EY0 66LEU Decreased Stability NA 0.330051 1.223 None N
24 Hydrophobic core mutations and stability 1EY0 23PHE Decreased Stability NA -0.146343 -0.4896 None Y
24 Hydrophobic core mutations and stability 1EY0 117GLY/124LEU/128ALA Increased Stability NA 5.0385 27.08 None Y
24 Hydrophobic core mutations and stability 1EY0 41ILE/117GLY/124LEU/128ALA Increased Stability NA 6.70359 23.12 None Y
24 Hydrophobic core mutations and stability 1EY0 33VAL/41ILE/117GLY/124LEU/128 ALA Increased Stability NA 7.70613 19.81 None Y
24 Hydrophobic core mutations and stability 1EY0 41ILE/59ALA/117GLY/124LEU/128ALA Increased Stability NA 7.67755 20.54 None Y
24 Hydrophobic core mutations and stability 1IGV 6VAL Decreased Stability NA 0.0122944 0.08159 CITED N
24 Hydrophobic core mutations and stability 1IGV 23ALA Decreased Stability NA -3.44568 -18.86 CITED Y
24 Hydrophobic core mutations and stability 1IGV 28ALA Decreased Stability NA -5.01899 -19.84 CITED Y
24 Hydrophobic core mutations and stability 1IGV 61ALA Decreased Stability NA -1.57148 -9.122 CITED Y
24 Hydrophobic core mutations and stability 1IGV 66TRP Decreased Stability NA -2.94373 -9.532 CITED Y
24 Hydrophobic core mutations and stability 1IGV 66ALA Decreased Stability NA -4.48216 -14.51 CITED Y
24 Hydrophobic core mutations and stability 1IGV 70LEU Decreased Stability NA 1.68757 8.082 CITED N
24 Hydrophobic core mutations and stability 1IGV 73VAL Decreased Stability NA -0.293993 -1.8 CITED Y
24 Hydrophobic core mutations and stability 1IGV 10ALA Decreased Stability NA -1.89606 -10.07 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 46 ALA Decreased Stability NA -4.05468 -16.76 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 71 ILE Decreased Stability NA 0.775502 4.331 CITED N
24 Hydrophobic core mutations and stability 1L63 1 71 MET Decreased Stability NA -2.22745 -9.504 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 71 PHE Decreased Stability NA -0.946425 -3.813 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 99 ALA Decreased Stability NA -5.16747 -15.6 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 100 ALA Decreased Stability NA -3.13296 -13.99 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 118 ALA Decreased Stability NA -3.70085 -13.68 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 121 ALA Decreased Stability NA -6.6029 -22.66 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 133 ALA Decreased Stability NA -0.484756 -8.425 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 153 VAL Decreased Stability NA -0.872702 -3.466 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 153 MET Decreased Stability NA -3.03033 -11.5 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 153 LEU Increased Stability NA 0.311064 1.151 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 153 ILE Decreased Stability NA -0.528307 -2.098 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 153 ALA Decreased Stability NA -5.04183 -19.4 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 17 ALA Decreased Stability NA -3.61058 -25.01 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 27 ALA Decreased Stability NA -4.0453 -19.97 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 50 ALA Decreased Stability NA -1.71107 -15.41 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 58 ALA Decreased Stability NA -4.12503 -22.66 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 78 ALA Decreased Stability NA -2.28121 -14.34 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 87 ALA Decreased Stability NA -1.80626 -9.307 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 103 ALA Decreased Stability NA -2.15333 -11.79 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 111 ALA Decreased Stability NA -2.31962 -12.8 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 67 ALA Decreased Stability NA -2.47922 -17.62 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 104 ALA Decreased Stability NA -2.68082 -17.46 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 66 ALA Decreased Stability NA -2.74624 -14.38 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 84 ALA Decreased Stability NA -3.23189 -17.26 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 91 ALA Decreased Stability NA -2.736 -15.61 CITED Y
24 Hydrophobic core mutations and stability 1L63 1 71 ALA Decreased Stability NA -3.2726 -14.62 CITED Y
80 CITED