My research combines experimental and theoretical techniques to investigate mechanisms in virology, immunology, and infectious disease epidemiology. Mathematical studies used in conjunction with data can suggest unforeseen biological mechanisms, determine biologically important rate parameters and evaluate pathogenic mechanisms that are difficult to test directly. A systems biology approach that couples mathematics with experiments has the potential to advance our basic understanding of pathogenic mechanisms and to lead to new therapeutic strategies.
Currently my research group is examining the control of lentiviral infection, including human immunodeficiency virus (HIV) and equine infectious anemia virus (EIAV). We use mathematical and computational models of viral dynamics with clinical and experimental data to elucidate the determinants of virus control and escape. Our long-term goal is to uncover fundamental viral or immune mechanisms and to develop effective vaccine strategies.
Other current projects investigate the epidemic spread of
influenza infection as well as viral evolution in
Schwartz EJ, Pawelek KA, Harrington K, Cangelosi R, Madrid S. (2013) Immune control of equine infectious anemia virus infection by CTLs and antibodies. To appear in Applied Mathematics.
Miller L, Jones T, Morgan M, Lapin S, Schwartz EJ. (2013) Individual-based computational model used to explain pandemic 2009 H1N1 in rural campus community. To appear in J. Biological Systems.
Mushayabasa S, Bhunu CP, Schwartz EJ, Magombedze G, Tchuenche JM. (2011) Socio-economic status and HIV/AIDS dynamics: a modeling approach. World Journal of Modeling and Simulation 7(4):243-57.
Snedecor SJ, Strutton D, Ciuryla V, Schwartz EJ, Botteman M. (2009) Transmission-dynamic model to capture the indirect effects of infant vaccination with Prevnar (7-valent pneumococcal conjugate vaccine (PCV7)) in older populations. Vaccine 27(34):4694-703.
Anton PA, Ibarrondo FJ, BoscardinWJ,
Zhou Y, Schwartz EJ, Ng HL, Hausner MA, Shih R, Elliott J,
Hultin PM, Hultin LE, Price C, Fuerst M, Adler A, Wong JT,
Yang OO, and Jamieson BD. (2008) Differential
Immunogenicity of Vaccinia and HIV-1 Components of a
Recombinant Vaccine in Mucosal and Blood Compartments.
Smith RJ, Schwartz EJ. (2008) Predicting the potential impact of a cytotoxic T lymphocyte HIV vaccine: how often should you vaccinate and how strong should the vaccine be? Math Biosci 212:180-187.
Schwartz EJ, Bodine EN, Blower S. (2007) Effectiveness and Efficiency of Imperfect Therapeutic HSV-2 Vaccines. Human Vaccines 3(6):231-238.
Schwartz EJ, Szczech LA, Ross MJ, Klotman ME, Winston JA, Klotman PE. (2005) Highly Active Antiretroviral Therapy and the Epidemic of HIV+ End-Stage Renal Disease. J Am Soc Nephrol 16(8):2412-20.
Schwartz EJ, Blower S. (2005) Predicting the Potential Individual- and Population-Level Effects of Imperfect Herpes Simplex Virus Type 2 Vaccines. J Infect Dis 191(10):1734-46.
Schwartz EJ, Fierer DS, Neumann AU, Keller MJ, Parkas V, Klotman ME, Winston JA, Klotman PE. (2002) HIV-1 Dynamics in Hemodialysis Patients. AIDS 16(9):1301-1303.
Schwartz EJ, Neumann AU, Teixeira AV, Bruggeman LA, Rappaport J, Perelson AS, Klotman PE. (2002) Effect of Target Cell Availability on HIV-1 Production in Vitro. AIDS 16(3):341-345.
Schwartz EJ, Cara A, Snoeck H, Ross MD, Sunamoto M, Reiser J, Mundel P, Klotman PE. (2001) HIV-1 Induces Loss of Contact Inhibition in Podocytes. J Am Soc Nephrol 12(8):1677-84.