COLLEGE OF ARTS AND SCIENCES Department of Mathematics and Statistics


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Applied Math Seminar: Ranking of CASP6 Predictions Using Statistical Potentials


3:10pm, Neill 3W

Kelly Stratton

Abstract: Critical Assessment of Structure Prediction (CASP) is a protein structure prediction competition held every other year. Groups can submit up to five predictions (x,y,z coordinates of all atoms in the protein) for each target sequence, whose structure is known, but not revealed. The groups also rank their predictions. Afterwards, the predictions are evaluated by comparing them to the actual structures. We test the effectiveness of a four-body scoring function to rank the predictions. We define a new measure called coefficient of prediction (CP) to evaluate the accuracy of our rankings. The four-body scoring function is quite accurate in ranking all predictions from various groups for each target. Further, we demonstrate that more accurate rankings would have been made by individual groups on average if they used our scoring function.